10 - DILATED CARDIOMYOPATHY IN CONSANGUINEOUS IRAQI PEDIATRIC CASES SERIES - PRE VERSUS POST COVID ERA

Background: The global COVID-19 pandemic has presented unprecedented challenges in the realm of pediatric healthcare, with the emergence of Multisystem Inflammatory Syndrome in Children (MIS-C) post-SARS-CoV-2 infection. Among the spectrum of cardiac complications associated with MIS-C, dilated cardiomyopathy has manifested as a significant concern, particularly in the context of consanguineous Iraqi pediatric cases. This abstract aims to explore the distinctive characteristics, diagnostic considerations, and management strategies specific to dilated cardiomyopathy in this unique demographic subset. 

Methods: A comprehensive retrospective case series study conducted on the last 13 years , with a specific focus on  dilated cardiomyopathy in consanguineous  Iraqi pediatric in both pre and post covid era. The analysis sought to elucidate the prevalence, clinical distribution , consanguinity , presence of CHD in the family and outcome for both groups .

Results: Total cases reached out were 70 cases among 43 cases in precovid and   27 cases of Dilated cardiomyopathy in consanguineous Iraqi pediatric cases in post-COVID MIS-C presents with unique prevalence patterns and clinical features with same presentation with different severity within the same family members or first degree relatives and with congenital heart disease includes 7 patients in 3 families  . consanguinity account for 62% in both groups . presences of family history of congenital heart disease in both groups nearly same  accounts for %22.9. outcome of both group were different 55% in post Vs 45% in precovid era .


Conclusion: underscores the nuanced challenges posed by dilated cardiomyopathy in consanguineous Iraqi pediatric cases in pre and  post-COVID MIS-C. Integrating genetic considerations into both diagnosis and management strategies is imperative for optimizing outcomes in this distinct population. Continued research efforts are warranted to deepen our understanding of the genetic landscape and refine therapeutic approaches for dilated cardiomyopathy within the context of post-COVID MIS-C in consanguineous Iraqi pediatric cases.